Cyp19a1 snp file
In another study, a CYP19A1 SNP was associated with a decrease in bone mineral density in postmenopausal women with ER-positive breast. To date, CYP19A1 polymorphisms have been identified (accessed: December 16, ). Recent studies. rs is a SNP in the CYP19A1 gene on chromosome The CYP19A1 gene is probably the primary one studied to date as possibly.
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CYP19A1 is related to estrogen, and both animal experiments and clinical observations have demonstrated that the occurrence of CAD is related to the levels of sex hormones in the body [ 16 — 18 ].
Filled boxes indicate coding regions. Genet Mol Res.
We randomly recruited Han men and women and Uygur men and 87 women patients with CAD as well as Han and Uygur individuals as ethnically and geographically matched control subjects.
Keywords: CYP19A1, coronary artery disease, sex hormone. SNP were consistent with the predicted Hardy-Weinberg equilibrium values . Expert Consensus Document of SCCT, ACR and NASCI: Endorsed by the ACC.
Studies have shown that the inhibition of aromatase activity can reduce the levels of estrogen, resulting in excessive accumulation of the androgen precursor [ 28 ].
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CYP19 gene polymorphisms and the susceptibility to breast cancer in Xinjiang Uigur women. CAD is considered a major cause of mortality worldwide, and the incidence of coronary events in women is increasing, with most events occurring after the onset of menopause [ 1 — 2 ].
Video: Cyp19a1 snp file
Endokrynol Pol. BMC Cancer.
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|Hence, aromatase has become the target for considerable research in the exploration of cancer association and a potential target for therapeutic interventions due to the significant role it plays in the synthesis of estrogens.
The demographic and clinical characteristics of CRC patients and the control group were obtained from interviewing the patients and from their hospital files and are presented in Table 1. A two-degree-of-freedom likelihood ratio test for homogeneity of the effect of each SNP was performed. It has confirmed our earlier observations during our studies that the frequencies of different SNPs in Saudi population differ considerably when compared to other populations thus any potential therapeutic development targeting this pathway in other populations might not be applicable to this population and emphasizes the notion of personalized treatment targets.
The presence of homozygous GG state decreased the OR to 0. Third, there is a lack of individual genetic background information for the Uygur subjects.